Formulation strategies in immunotherapeutic pharmaceutical products

Immunotherapeutic strategies for bladder cancer

Bladder cancer is a common urologic malignancy with rising incidence in the elderly population. In most cases, bladder cancer is non-muscle-invasive at diagnosis and shows dramatically high recurrence rates, although current treatments often reduce the risk of disease progression. Immunotherapy using intravesical instillation of Bacillus Calmette-Guérin (BCG) remains the most effective therapy ...

Immunotherapeutic strategies for malignant glioma.

BACKGROUND Despite advances in surgery, radiation therapy, and chemotherapy, only modest improvement has been achieved in the survival of patients with malignant gliomas. METHODS The authors review the immunologic aspects of gliomas, potential targets for therapy, and issues surrounding current immunotherapeutic strategies directed against malignant gliomas. RESULTS The blood-brain barrier ...

Immunotherapeutic Strategies for Brain Tumors

Cancer immunotherapy is the use of the immune system to reject cancers. The main premise is to harness the patient's immune system to attack the malignant tumor cells. This area of research has made tremendous progresses, and the United States Food and Drug Administration recently approved a vaccine for prostate cancers as the first approval for vaccines against non-viral cancers (Kantoff et al...

Gelatin Nanoparticles as a Modern Platform for Drug Delivery - Formulation Development and Immunotherapeutic Strategies

Pharmaceutical Engineering: Optimization of a Pharmaceutical Formulation

The effects of magnesium stearate (MgSt) and shear stress on flow properties and hydrophobicity are not well known. Blends with different concentrations of magnesium stearate and varying amounts of shear were tested using three different procedures: the FT4 Rheometer test, a tap density analyzer, and the Washburn method, to better understand the relation of lubricant concentration, amount of sh...